1-Boc-3-aminopyrrolidine → 3-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 14798

반응식

HRID 14798 반응식
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH:11]=O)[CH:5]=[CH:4][N:3]=1.[C:16]([O:20][C:21]([N:23]1[CH2:27][CH2:26][CH:25]([NH2:28])[CH2:24]1)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([N:23]1[CH2:27][CH2:26][CH:25]([NH:28][CH2:11][C:10]2[CH:13]=[CH:14][CH:15]=[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=3)[CH:9]=2)[CH2:24]1)=[O:22])([CH3:19])([CH3:17])[CH3:18]

참가 물질

3

반응물 2

HCID 27563701-Boc-3-aminopyrrolidineHCID 249019653-(2-Chloro-pyrimidin-4-yl)-benzaldehyde

생성물 1

HCID 866032683-[3-(2-Chloro-pyrimidin-4-yl)-benzylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester

실험 절차

Intermediate 1 was coupled with 3-Amino-pyrrolidine-1-carboxylic acid tert-butyl ester following procedure B. LC-MS showed the product had the expected M+H+ of 389.

출처 및 근거

ORD 기록
ord-717a36b195fc45dfabe1675aacd40eca
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732444B2

연결된 노트

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