Diethyl Pyrocarbonate → 2-[(4-fluorophenyl)sulfonyl-methyl-amino]-N-[[2-[4-(trifluoromethyl)phenyl]-4-pyridyl]methyl]prop-2-enamide

HRID 1479882노트

반응식

HRID 1479882 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH3:17])[C:12](=[CH2:16])[C:13]([OH:15])=O)(=[O:10])=[O:9])=[CH:4][CH:3]=1.CCOC(OC(OCC)=O)=O.[F:29][C:30]([F:46])([F:45])[C:31]1[CH:36]=[CH:35][C:34]([C:37]2[CH:42]=[C:41]([CH2:43][NH2:44])[CH:40]=[CH:39][N:38]=2)=[CH:33][CH:32]=1>C1COCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([N:11]([CH3:17])[C:12](=[CH2:16])[C:13]([NH:44][CH2:43][C:41]2[CH:40]=[CH:39][N:38]=[C:37]([C:34]3[CH:35]=[CH:36][C:31]([C:30]([F:46])([F:29])[F:45])=[CH:32][CH:33]=3)[CH:42]=2)=[O:15])(=[O:9])=[O:10])=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 3051Diethyl PyrocarbonateHCID 68758847[2-(4-Trifluoromethyl-phenyl)-pyridin-4-yl]methylamineHCID 1317365812-[(4-Fluorophenyl)sulfonyl-methyl-amino]prop-2-enoic acid

생성물 1

HCID 783199102-[(4-fluorophenyl)sulfonyl-methyl-amino]-N-[[2-[4-(trifluoromethyl)phenyl]-4-pyridyl]methyl]prop-2-enamide수율 49%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of acid 4A (260 mg, 1 mmol) in THF (25 mL) was added with DEPC (0.18 mL, 1.3 mol eq) and the mixture was stirred at room temperature for about 5 minutes. Then [2-[4-(trifluoromethyl)phenyl]-4-pyridyl]methanamine 21A (1.1 equiv., 277.5 mg) was added. The reaction mixture was then stirred at room temperature overnight. The solvent was removed under reduced pressure, the residue was suspended in EtOAc (30 mL) and washed with water (50 mL) and brine. The separated organic phase, after anhydrification over Na2SO4, was evaporated under reduced pressure and the residue was purified by flash chromatography (1:1 EtOAc:Petroleum ether) to afford a pale yellow solid (100 mg) after crystallization from a mixture of diethyl ether/petroleum ether. Yield=49%, 1HNMR (DMSO, 400 MHz) δ 2.93 (3H, s), 4.48 (d, 2H, J=6 Hz), 5.08 (s, 1H), 5.87 (s, 1H), 7.35 (d, 1H), 7.37 (t, 2H, J=8.8 Hz), 7.82 (m, 4H), 8.03 (s, 1H), 8.28 (d, 2H, J=8.4 Hz), 8.63 (d, 1H, J=5.2 Hz), 8.95 (bt, 1H); [M+1] 494.47 (C23H19F4N3O3S requires 493.47).

후처리

  1. stirringThe reaction mixture was then stirred at room temperature overnight
  2. customThe solvent was removed under reduced pressure
  3. washwashed with water (50 mL) and brine
  4. customThe separated organic phase, after anhydrification over Na2SO4, was evaporated under reduced pressure
  5. customthe residue was purified by flash chromatography (1:1 EtOAc:Petroleum ether)

출처 및 근거

ORD 기록
ord-e377c2f9315f4fdbb1f1d8d42c1d506b
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409864B2

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