L-Leucinol → 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide

HRID 1480044

반응식

[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:16][C@@H:17]([CH2:20][CH:21]([CH3:23])[CH3:22])[CH2:18][OH:19]>>[OH:19][CH2:18][C@@H:17]([NH:16][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])[CH2:20][CH:21]([CH3:23])[CH3:22]

참가 물질

반응물 2

HCID 111307L-Leucinol

HCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

생성물 1

HCID 762827175-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 1, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and (2S)-2-amino-4-methyl-1-pentanol (CAN 7533-40-6) as starting materials and isolated (19.4 mg, 59%) as white solid; MS (ESI, m/z): 327.1 (MH+).

후처리

customisolated (19.4 mg, 59%) as white solid

출처 및 근거

ORD 기록: ord-3b6adb7b17554f9fa36b89100e113248
출처 데이터셋: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09409866B2

연결된 노트

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