2-Amino-2-methylbutan-1-ol → 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-hydroxymethyl-1-methyl-propyl)-amide

반응식

[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:16][C:17]([CH3:22])([CH2:20][CH3:21])[CH2:18][OH:19]>>[OH:19][CH2:18][C:17]([NH:16][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])([CH3:22])[CH2:20][CH3:21]

참가 물질

반응물 2

HCID 101540172-Amino-2-methylbutan-1-ol

HCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

생성물 1

HCID 762832145-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-hydroxymethyl-1-methyl-propyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 1, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and 2-amino-2-methyl-1-butanol (CAN 10196-30-2) as starting materials and isolated (75 mg, 55%) as colorless oil; LC-MS (UV peak area, m/z) 100%, 313.1322 (MH+).

후처리

customisolated (75 mg, 55%) as colorless oil

출처 및 근거

ORD 기록: ord-990f73056e34403f84beb4b4a2450c0c
출처 데이터셋: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09409866B2

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