2,2-Dimethyl-1-thiazol-2-yl-propylamine → 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (2,2-dimethyl-1-thiazol-2-yl-propyl)-amide

HRID 1480091

반응식

HRID 1480091 반응식
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][CH:15]3[CH2:17][CH2:16]3)=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[CH3:18][C:19]([CH3:28])([CH3:27])[CH:20]([NH2:26])[C:21]1[S:22][CH:23]=[CH:24][N:25]=1>>[CH3:18][C:19]([CH3:28])([CH3:27])[CH:20]([NH:26][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][CH:15]2[CH2:17][CH2:16]2)[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12])[C:21]1[S:22][CH:23]=[CH:24][N:25]=1

참가 물질

3

반응물 2

HCID 207955242,2-Dimethyl-1-thiazol-2-yl-propylamineHCID 902038095-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

생성물 1

HCID 762829655-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (2,2-dimethyl-1-thiazol-2-yl-propyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 24d, using 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42c) and 2,2-Dimethyl-1-thiazol-2-yl-propylamine (CAN 1247122-26-4) as starting materials and isolated (15 mg, 26%) as white solid; MS (ESI, m/z): 386.4 (M+H+).

후처리

  1. customisolated (15 mg, 26%) as white solid

출처 및 근거

ORD 기록
ord-4094aadb2779495abb55500680294cdb
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409866B2

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