2-Amino-2-ethyl-N-methyl-butyramide hydrochloride → 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

HRID 1480095

반응식

HRID 1480095 반응식
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][CH:15]3[CH2:17][CH2:16]3)=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.Cl.[NH2:19][C:20]([CH2:27][CH3:28])([CH2:25][CH3:26])[C:21]([NH:23][CH3:24])=[O:22]>>[CH2:25]([C:20]([NH:19][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][CH:15]2[CH2:17][CH2:16]2)[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12])([C:21](=[O:22])[NH:23][CH3:24])[CH2:27][CH3:28])[CH3:26]

참가 물질

3

반응물 2

HCID 895221382-Amino-2-ethyl-N-methyl-butyramide hydrochlorideHCID 902038095-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

생성물 1

HCID 902038715-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 24d, using 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42c) and 2-Amino-2-ethyl-N-methyl-butyramide hydrochloride (Example 45c) as starting materials and isolated (23 mg, 71%) as colorless oil; MS (ESI, m/z): 360.6 (M+H+).

후처리

  1. customisolated (23 mg, 71%) as colorless oil

출처 및 근거

ORD 기록
ord-5e8cc3b8c1e74f90a5df7d7e17472dc8
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409866B2

연결된 노트

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