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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1480214생성일: 2026년 10월 26일

2-Amino-3-cyclopropyl-2-methyl-propionitrile → N-(2-cyano-1-cyclopropylpropan-2-yl)-5-(3-fluorooxetan-3-yl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridine-2-carboxamide

https://huagongshe.com/reaction/1480214

반응식

참여 물질

역할이름HCID투입량
반응물2-Amino-3-cyclopropyl-2-methyl-propionitrileHCID 84716049—
반응물5-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acidHCID 90214950—
생성물N-(2-cyano-1-cyclopropylpropan-2-yl)-5-(3-fluorooxetan-3-yl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridine-2-carboxamideHCID 90203420—

반응 단계

The title compound was synthesized in analogy to Example 112e, using 5-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acid (Example 142b) and 2-Amino-3-cyclopropyl-2-methyl-propionitrile (example 66a) as starting materials and isolated (27.5 mg, 26%); MS (ESI, m/z): 416.5 (M+H+).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09409866B2
출처 데이터셋uspto-grants-2016_08
ORD IDord-744141fe08314e8fa65c0944c018bb43
출처 메모uspto-grants-2016_08