1-Cyclopropyl-2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-2-amine → N-[1-cyclopropyl-2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-2-yl]-5-(3-fluorooxetan-3-yl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridine-2-carboxamide

HRID 1480249노트

반응식

HRID 1480249 반응식
[F:1][C:2]1([C:6]2[C:7]([O:15][C@@H:16]([CH3:21])[C:17]([F:20])([F:19])[F:18])=[CH:8][C:9]([C:12]([OH:14])=O)=[N:10][CH:11]=2)[CH2:5][O:4][CH2:3]1.[CH:22]1([CH2:25][C:26]([C:29]2[O:30][C:31]([CH3:34])=[N:32][N:33]=2)([NH2:28])[CH3:27])[CH2:24][CH2:23]1>>[CH:22]1([CH2:25][C:26]([NH:28][C:12]([C:9]2[CH:8]=[C:7]([O:15][C@@H:16]([CH3:21])[C:17]([F:18])([F:20])[F:19])[C:6]([C:2]3([F:1])[CH2:5][O:4][CH2:3]3)=[CH:11][N:10]=2)=[O:14])([C:29]2[O:30][C:31]([CH3:34])=[N:32][N:33]=2)[CH3:27])[CH2:24][CH2:23]1

참가 물질

3

반응물 2

HCID 902046221-Cyclopropyl-2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-2-amineHCID 902149505-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acid

생성물 1

HCID 90203518N-[1-cyclopropyl-2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-2-yl]-5-(3-fluorooxetan-3-yl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridine-2-carboxamide

실험 절차

The title compound was synthesized in analogy to Example 112e, using 5-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acid (example 142b) and 1-cyclopropyl-2-(5-methyl-1,3,4-oxadiazol-2-yl)propan-2-amine (example 173b) as starting materials and isolated (70 mg, 46%); MS (ESI, m/z): 473.5 (M+H+).

후처리

  1. customisolated (70 mg, 46%)

출처 및 근거

ORD 기록
ord-24e7e7dc2e914711b747f1c98e381b8a
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409866B2

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