D-(-)-Tert-butyl tert-leucinate → tert-butyl 2-[[5-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carbonyl]amino]-3,3-dimethyl-butanoate

HRID 1480272

반응식

HRID 1480272 반응식
[CH:1]1([C:4]2[C:5]([O:13][C@@H:14]([CH3:19])[C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[C:20]([O:24][C:25](=[O:32])[CH:26]([NH2:31])[C:27]([CH3:30])([CH3:29])[CH3:28])([CH3:23])([CH3:22])[CH3:21]>>[CH:1]1([C:4]2[C:5]([O:13][C@@H:14]([CH3:19])[C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([NH:31][CH:26]([C:27]([CH3:30])([CH3:29])[CH3:28])[C:25]([O:24][C:20]([CH3:22])([CH3:21])[CH3:23])=[O:32])=[O:12])=[N:8][CH:9]=2)[CH2:2][CH2:3]1

참가 물질

3

반응물 2

HCID 12490703D-(-)-Tert-butyl tert-leucinateHCID 902045735-Cyclopropyl-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid

생성물 1

HCID 90214929tert-butyl 2-[[5-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carbonyl]amino]-3,3-dimethyl-butanoate

실험 절차

The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid (Example 68a) and 2-Amino-3,3-dimethyl-butyric acid tert-butyl ester (CAN 99285-38-8) as starting materials and isolated (526 mg, 87%); MS (ESI, m/z): 445.6 (M+H+).

후처리

  1. customisolated (526 mg, 87%)

출처 및 근거

ORD 기록
ord-f41c6b010c7b4bada717b20b47f0778c
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409866B2

연결된 노트

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