Methanol → 2-(3-amino-1,1-dioxo-thietan-3-yl)-N-methyl-acetamide

HRID 1480334노트

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[NH2:1][C:2]1([CH2:8][C:9]([O:11]CC)=O)[CH2:5][S:4](=[O:7])(=[O:6])[CH2:3]1.CO.[CH3:16][NH2:17]>>[NH2:1][C:2]1([CH2:8][C:9]([NH:17][CH3:16])=[O:11])[CH2:5][S:4](=[O:7])(=[O:6])[CH2:3]1

참가 물질

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HCID 887Methanol

HCID 6329Methylamine

HCID 90202743Ethyl (3-amino-1,1-dioxido-3-thietanyl)acetate

생성물 1

HCID 902149512-(3-amino-1,1-dioxo-thietan-3-yl)-N-methyl-acetamide수율 99%

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온도: 45 °C

실험 절차

ethyl 2-(3-amino-1,1-dioxo-thietan-3-yl)acetate (example 160c, 548 mg, 2.64 mmole) was dissolved in a solution 2.0M of methylamine in methanol (19.8 mL, 39.7 mmole) and the reaction mixture was stirred at 45° C. overnight. Removal of volatiles in vacuo yielded the title compound (505 mg, 99%) as crude light brown oil which was used without any further purification; MS (ESI, m/z): 193.1 (M+H+).

후처리

customRemoval of volatiles in vacuo

출처 및 근거

ORD 기록: ord-9fc7c4fea7004a0c9d0b15e5f1b5e251
출처 데이터셋: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09409866B2

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