Sodium Bicarbonate → 3,5-Dichlorobenzyl 4-(((tert-butoxycarbonyl)amino)methyl)piperidine-1-carboxylate

HRID 1480447노트

반응식

HRID 1480447 반응식
[C:1]([O:5][C:6](=[O:15])[NH:7][CH2:8][CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1)([CH3:4])([CH3:3])[CH3:2].[C:16](Cl)(=[O:27])[O:17][CH2:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[C:21]([Cl:26])[CH:20]=1.C(=O)(O)[O-].[Na+]>C(Cl)Cl>[C:1]([O:5][C:6]([NH:7][CH2:8][CH:9]1[CH2:10][CH2:11][N:12]([C:16]([O:17][CH2:18][C:19]2[CH:20]=[C:21]([Cl:26])[CH:22]=[C:23]([Cl:25])[CH:24]=2)=[O:27])[CH2:13][CH2:14]1)=[O:15])([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 723429Tert-butyl (piperidin-4-ylmethyl)carbamateHCID 133055323,5-Dichlorobenzyl Chloroformate

생성물 1

HCID 867226733,5-Dichlorobenzyl 4-(((tert-butoxycarbonyl)amino)methyl)piperidine-1-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A reaction mixture comprising tert-butyl(piperidin-4-ylmethyl)carbamate (1 g, 4.67 mmol), 3,5-dichlorobenzyl carbonochloridate, (1.117 g, 4.67 mmol) and sodium bicarbonate (15 mL, 4.67 mmol) in DCM (15.55 mL) was stirred at room temperature for 18 hours. The reaction mixture was separated and the organic portion was dried over MgSO4, filtered and solvent concentrated under reduced pressure to give the title compound as a yellow oil;

후처리

  1. customThe reaction mixture was separated
  2. dry with materialthe organic portion was dried over MgSO4
  3. filtrationfiltered
  4. concentrationsolvent concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-fecbfd67cca84c1982b42e36489e7067
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409895B2

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