Trifluoroacetic acid → HCID 86722684, 화합물

HRID 1480458노트

반응식

HRID 1480458 반응식
C(OC([NH:8][CH:9]1[CH2:13][CH2:12][N:11]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[C:22]([Cl:24])[CH:21]=[C:20]([Cl:25])[CH:19]=2)=[O:15])[CH2:10]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:8][CH:9]1[CH2:13][CH2:12][N:11]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[C:22]([Cl:24])[CH:21]=[C:20]([Cl:25])[CH:19]=2)=[O:15])[CH2:10]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 867226833,5-Dichlorobenzyl 3-((tert-butoxycarbonyl)amino)pyrrolidine-1-carboxylate

생성물 1

HCID 86722684HCID 86722684, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture comprising of 3,5-dichlorobenzyl 3-((tert-butoxycarbonyl)amino)pyrrolidine-1-carboxylate (1.8143 g, 4.66 mmol) and trifluoroacetic acid (14.36 ml, 186 mmol) in DCM (15.54 ml) was stirred at RT for 2 hours. The reaction mixture was concentrated under reduced pressure, diluted with DCM and washed with water. The organic portion was separated, dried over MgSO4, filtered and concentrated under reduced pressure to form an orange oil which was used in the next step without further purification;

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additiondiluted with DCM
  3. washwashed with water
  4. customThe organic portion was separated
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure
  8. customto form an orange oil which
  9. customwas used in the next step without further purification

출처 및 근거

ORD 기록
ord-0884cdf38b7a4395ab27c2cc9be126fc
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409895B2

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