Thionyl Chloride → HCID 178521140, 화합물

HRID 1480460노트

반응식

HRID 1480460 반응식
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][C:9]([OH:11])=O)[N:3]=[N:2]1.S(Cl)([Cl:14])=O>C(Cl)Cl>[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][C:9]([Cl:14])=[O:11])[N:3]=[N:2]1

참가 물질

4

반응물 2

HCID 24386Thionyl Chloride2회HCID 178525383HCID 178525383, 화합물

생성물 1

HCID 178521140HCID 178521140, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution/suspension of 4-(1H-1,2,3-triazol-4-yl)butanoic acid (150 mg, 0.967 mmol) in dry DCM (10 mL) was added thionyl chloride (0.847 mL, 11.60 mmol) at RT. After 30 mins some solid still remained so a further 0.4 ml thionyl chloride was added and the reaction mixture allowed to stir at RT for 2 hrs. The reaction mixture was concentrated under reduced pressure to afford the title product which was used in the next step without further purification.

후처리

  1. additionwas added
  2. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d9d9817ae2ec4bafa63d006f8796184c
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409895B2

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