Thionyl Chloride → 5-(1H-1,2,3-triazol-4-yl)pentanoyl chloride

HRID 1480486노트

반응식

HRID 1480486 반응식
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=O)[N:3]=[N:2]1.S(Cl)([Cl:15])=O>C(Cl)Cl>[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][CH2:9][C:10]([Cl:15])=[O:12])[N:3]=[N:2]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 178525394HCID 178525394, 화합물

생성물 1

HCID 1785211415-(1H-1,2,3-triazol-4-yl)pentanoyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a suspension of 5-(1H-1,2,3-triazol-4-yl)pentanoic acid (Example 20, step 3) (100 mg, 0.591 mmol) in DCM (5 mL) at RT under nitrogen was added thionyl chloride (0.518 mL, 7.09 mmol). The reaction mixture was stirred at rt for 2 hours and concentrated under reduced pressure to afford the title product.

후처리

  1. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-08be552838884099b2e8a1e388cb9af7
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409895B2

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