HCID 68290880, 화합물 → HCID 89996160, 화합물
반응식
FC(F)(F)S(O[C:7]1[N:8]=[CH:9][C:10]2[C:15]([CH:16]=1)=[C:14]([NH:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)[N:13]=[CH:12][CH:11]=2)(=O)=O.[CH3:26][O:27][C:28]1[CH:34]=[C:33]([C:35]2[CH:36]=[N:37][N:38]([CH3:40])[CH:39]=2)[CH:32]=[CH:31][C:29]=1[NH2:30]>>[CH:18]1([NH:17][C:14]2[C:15]3[C:10](=[CH:9][N:8]=[C:7]([NH:30][C:29]4[CH:31]=[CH:32][C:33]([C:35]5[CH:36]=[N:37][N:38]([CH3:40])[CH:39]=5)=[CH:34][C:28]=4[O:27][CH3:26])[CH:16]=3)[CH:11]=[CH:12][N:13]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1참가 물질
3
실험 절차
The title compound was prepared according to Method 6 (Example 103) using 5-(cyclohexylamino)-2,6-naphthyridin-3-yl trifluoromethanesulfonate (Preparation 93) and 2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)aniline (Preparation 19) for 18 hours. The residue was purified using silica gel column chromatography eluting with 0-10% MeOH in DCM.
후처리
- customfor 18 hours
- customThe residue was purified
- washeluting with 0-10% MeOH in DCM
출처 및 근거
- ORD 기록
- ord-c13eaa50e44f4f469b63e501946a8bd7
- 출처 데이터셋