Formic Acid → HCID 89996059, 화합물

반응식

[CH3:1][O:2][C:3]1[C:8]([NH2:9])=[CH:7][CH:6]=[C:5]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[N:4]=1.[CH:16](O)=[O:17]>>[CH3:1][O:2][C:3]1[C:8]([NH:9][CH:16]=[O:17])=[CH:7][CH:6]=[C:5]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[N:4]=1

참가 물질

반응물 2

HCID 284Formic Acid

HCID 12152132526184-47-4

생성물 1

HCID 89996059HCID 89996059, 화합물수율 88%

실험 절차

A solution of 2-methoxy-6-morpholinopyridin-3-amine (Preparation 70, 40 mg, 0.191 mmol) in formic acid (3 mL) was heated to reflux for 3 hours. The reaction mixture was concentrated in vacuo. The residue was partitioned between aqueous saturated NaHCO3 (40 mL) and EtOAc (40 mL). The aqueous layer was re-extracted with EtOAc (40 mL). The combined organic layers were washed with water (40 mL) and brine (40 mL), dried (MgSO4) and concentrated in vacuo, to give the title compound (40 mg, 88%).

후처리

temperatureto reflux for 3 hours
concentrationThe reaction mixture was concentrated in vacuo
customThe residue was partitioned between aqueous saturated NaHCO3 (40 mL) and EtOAc (40 mL)
extractionThe aqueous layer was re-extracted with EtOAc (40 mL)
washThe combined organic layers were washed with water (40 mL) and brine (40 mL)
dry with materialdried (MgSO4)
concentrationconcentrated in vacuo

출처 및 근거

ORD 기록: ord-32ce2748e4284442922b4f18630c6df5
출처 데이터셋: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09409907B2

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