Triethylamine → HCID 89996006, 화합물

HRID 1480835노트

반응식

HRID 1480835 반응식
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:16]=[CH:15][CH:14]=[C:13]3[C:8]=2[CH:9]=[C:10]([OH:17])[N:11]=[CH:12]3)[CH:4]=[N:3]1.[O:18](S(C(F)(F)F)(=O)=O)[S:19]([C:22]([F:25])([F:24])[F:23])(=O)=[O:20].C(N(CC)CC)C>C(Cl)Cl>[F:23][C:22]([F:25])([F:24])[S:19]([O:17][C:10]1[N:11]=[CH:12][C:13]2[C:8]([CH:9]=1)=[C:7]([C:5]1[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=1)[N:16]=[CH:15][CH:14]=2)(=[O:20])=[O:18]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 67749Trifluoromethanesulfonic anhydrideHCID 178480127HCID 178480127, 화합물

생성물 1

HCID 89996006HCID 89996006, 화합물수율 59.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 5-(1-methyl-1H-pyrazol-4-yl)-2,6-naphthyridin-3-ol (Preparation 89, 15 mg, 0.066 mmol) in DCM (0.5 mL) was added Tf2O (0.013 mL, 0.080 mmol) and triethylamine (9.3 uL, 0.066 mmol). The reaction mixture was stirred at room temperature under 1 hour. The reaction mixture was concentrated in vacuo. The residue was passed through a SCX-2 cartridge eluting with 100% MeOH—1M NH3 in MeOH to give the title compound (14 mg, 59%).

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. washeluting with 100% MeOH—1M NH3 in MeOH

출처 및 근거

ORD 기록
ord-1f2812c9063c446cb3e92e33b2ad03f1
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409907B2

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