4-Morpholinopiperidine → 4-[1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl]morpholine

반응식

F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH3:12])[CH:3]=1.[NH:13]1[CH2:18][CH2:17][CH:16]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH2:15][CH2:14]1>>[CH3:12][O:11][C:4]1[CH:3]=[C:2]([N:13]2[CH2:18][CH2:17][CH:16]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[CH2:15][CH2:14]2)[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9]

참가 물질

반응물 2

HCID 7957244-Morpholinopiperidine

HCID 27792505-Fluoro-2-nitroanisole

생성물 1

HCID 574161544-[1-(3-Methoxy-4-nitrophenyl)piperidin-4-yl]morpholine

실험 절차

The title compound was prepared according to the method described for Preparation 78 using 4-fluoro-2-methoxy-1-nitrobenzene and 4-(piperidin-4-yl)morpholine. The residue was purified using silica gel column chromatography eluting with 80-100% DCM in cyclohexanes.

후처리

customThe residue was purified
washeluting with 80-100% DCM in cyclohexanes

출처 및 근거

ORD 기록: ord-684b0b21b168427d8842dd17a318efb4
출처 데이터셋: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09409907B2

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