1-(Methylsulfonyl)piperazine → 1-(3-Methoxy-4-nitro-phenyl)-4-methylsulfonyl-piperazine

HRID 1480879노트

반응식

HRID 1480879 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH3:12])[CH:3]=1.[CH3:13][S:14]([N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)(=[O:16])=[O:15]>>[CH3:12][O:11][C:4]1[CH:3]=[C:2]([N:20]2[CH2:21][CH2:22][N:17]([S:14]([CH3:13])(=[O:16])=[O:15])[CH2:18][CH2:19]2)[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9]

참가 물질

3

반응물 2

HCID 7091611-(Methylsulfonyl)piperazineHCID 27792505-Fluoro-2-nitroanisole

생성물 1

HCID 598602551-(3-Methoxy-4-nitro-phenyl)-4-methylsulfonyl-piperazine

실험 절차

The title compound was prepared according to the method described for Preparation 78 using 4-fluoro-2-methoxy-1-nitrobenzene and 1-(methylsulfonyl)piperazine for 96 hours. The residue was purified by silica gel column chromatography eluting with 50-100% DCM in cyclohexanes.

후처리

  1. customThe residue was purified by silica gel column chromatography
  2. washeluting with 50-100% DCM in cyclohexanes

출처 및 근거

ORD 기록
ord-1d5cb459ac8f464a90470f2296702634
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409907B2

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