Piperidine → (2S)-4-amino-2-(((tert-butoxy)carbonyl)amino)butanoic acid

HRID 1481020노트

반응식

HRID 1481020 반응식
[NH:1]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C@H:2]([C:23]([OH:25])=[O:24])[CH2:3][CH2:4][NH:5]C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.N1CCCCC1>CN(C=O)C>[NH2:5][CH2:4][CH2:3][C@H:2]([NH:1][C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[C:23]([OH:25])=[O:24]

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 2755945Boc-Dab(Fmoc)-OH

생성물 1

HCID 7019666(2S)-4-amino-2-(((tert-butoxy)carbonyl)amino)butanoic acid

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Boc-L-Dab(Fmoc)-OH (132 mg, 0.3 mmol, PepTech) and piperidine (0.2 mL, 2.02 mmol) were dissolved in DMF (1 mL). The resulting mixture was stirred at room temperature for 30 minutes. The volatiles were removed in vacuo and the residue was used directly in the subsequent step without further purification.

후처리

  1. customThe volatiles were removed in vacuo
  2. customthe residue was used directly in the subsequent step without further purification

출처 및 근거

ORD 기록
ord-e6a05d0cb9c749679e54cfa24643962d
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409892B2

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