Ethanol → 4-Hydroxy-7-phenethyl-isoquinoline-3-carboxylic acid methyl ester

HRID 1481135노트

반응식

HRID 1481135 반응식
[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([C:16]#[C:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH:9]=2)=[O:4].CCO>[Pd].CCOC(C)=O>[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH:9]=2)=[O:4]

참가 물질

5

반응물 2

HCID 702EthanolHCID 89812978HCID 89812978, 화합물

생성물 1

HCID 898128624-Hydroxy-7-phenethyl-isoquinoline-3-carboxylic acid methyl ester수율 569.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 4-hydroxy-7-phenylethynyl-isoquinoline-3-carboxylic acid methyl ester (60 mg, 0.20 mmol), 10% Pd/C (200 mg), EtOH (10 mL) and EtOAc (20 mL) was stirred under H2 atmosphere for 48 h. The resulting mixture was filtered, and the filtrate was concentrated. The residue was purified by column chromatography (0-40% EtOAc/hexanes) to give 350 mg of the title compound. MS: (+) m/z 308.26 (M+1).

후처리

  1. filtrationThe resulting mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by column chromatography (0-40% EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-1d619125794c498e8fc1f61b0fa699a2
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409892B2

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