Benzylurea → 7-(3-Benzyl-ureido)-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester

HRID 1481159노트

반응식

HRID 1481159 반응식
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[C:14]([C:15]=1[OH:16])=[CH:13][CH:12]=[C:11](Br)[CH:10]=2)=[O:5])[CH3:2].[CH2:18]([NH:25][C:26]([NH2:28])=[O:27])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[C:14]([C:15]=1[OH:16])=[CH:13][CH:12]=[C:11]([NH:28][C:26]([NH:25][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:27])[CH:10]=2)=[O:5])[CH3:2]

참가 물질

3

반응물 2

HCID 10853BenzylureaHCID 89813095Ethyl 7-bromo-4-hydroxyisoquinoline-3-carboxylate

생성물 1

HCID 898129357-(3-Benzyl-ureido)-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester

실험 절차

7-(3-Benzyl-ureido)-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester was prepared from 7-bromo-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester under conditions analogous to Example 116(a) using benzyl urea. The crude product was used in the following steps without purification.

후처리

  1. customThe crude product was used in the following steps without purification

출처 및 근거

ORD 기록
ord-903b8f274c344b76a30020c6768cd8a8
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409892B2

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