Water → Erythromycin Thiocyanate

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Crude erythromycin (a mixture of erythromycin and other impurities) (30 g) was added into pure water (300 mL). The solution was stirred. Glacial acetic acid 20% (9.9 mL) was slowly added dropwise to the solution followed by stirring for 20 minutes. Then the mixture was filtered to remove the insoluble impurities in crude. Sodium thiocyanate solution 20% (18.4 mL, 0.038 mol) was added dropwise into the filtrate. The solution was stirred, adjusted to pH 7.2, and allowed to react for 1.5 h. After precipitation, the mixture was cooled for crystallization. The precipitate was filtered and washed with pure water for 3 times, and then dried to obtain erythromycin thiocyanate. The amount of the main component dried erythromycin A was 74.3% (detected by HPLC).

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