Dimethyl methoxymethylenemalonate → HCID 71284791, 화합물

HRID 1481681노트

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HRID 1481681 반응식
CC([N:5]=[C:6]([C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[N:16]([CH3:20])[CH2:15][CH2:14][CH2:13]2)[CH2:7][CH2:8][CH3:9])(C)C.C[O:22][CH:23]=[C:24]([C:29]([O:31][CH3:32])=[O:30])[C:25](OC)=O>COCCOCCOC>[CH2:8]([C:7]1[CH:25]=[C:24]([C:29]([O:31][CH3:32])=[O:30])[C:23](=[O:22])[NH:5][C:6]=1[C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[N:16]([CH3:20])[CH2:15][CH2:14][CH2:13]2)[CH3:9]

참가 물질

4

반응물 2

HCID 90770Dimethyl methoxymethylenemalonateHCID 89422940HCID 89422940, 화합물

생성물 1

HCID 71284791HCID 71284791, 화합물수율 17.1%

시약·촉매·용매 1

HCID 8150Diglyme용매

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온도
160 °C

실험 절차

To a suspension of 2-methyl-N-(1-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)butylidene)propan-2-amine (1.96 g, ca. 7.2 mmol) in diglyme (7 mL) was added dimethyl 2-(methoxymethylene)malonate (2.12 g, 12.2 mmol, 1.7 eq). The reaction was stirred at 160° C. for 3 h then was cooled to room temperature. The precipitate was collected by filtration then washed with Et2O to afford the title compound (402 mg, ca. 1.23 mmol) which was carried over to next step without further purification.

후처리

  1. temperaturethen was cooled to room temperature
  2. filtrationThe precipitate was collected by filtration
  3. washthen washed with Et2O

출처 및 근거

ORD 기록
ord-25bf2ced89464f15b55c79841e0b3abd
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409905B2

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