Lithium iodide → HCID 71282062, 화합물

HRID 1481684노트

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HRID 1481684 반응식
[CH2:1]([C:3]1[C:4]([OH:25])=[C:5]([C:21]([O:23]C)=[O:22])[C:6](=[O:20])[NH:7][C:8]=1[C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]([CH3:19])[CH2:14][CH2:13][CH2:12]2)[CH3:2].[I-].[Li+]>CCOC(C)=O>[CH2:1]([C:3]1[C:4]([OH:25])=[C:5]([C:21]([OH:23])=[O:22])[C:6](=[O:20])[NH:7][C:8]=1[C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]([CH3:19])[CH2:14][CH2:13][CH2:12]2)[CH3:2]

참가 물질

4

반응물 2

HCID 66321Lithium iodideHCID 71284563HCID 71284563, 화합물

생성물 1

HCID 71282062HCID 71282062, 화합물수율 61%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

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온도
65 °C

실험 절차

To a suspension of methyl 5-ethyl-4-hydroxy-6-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)-2-oxo-1,2-dihydropyridine-3-carboxylate (34 mg, 0.1 mmol) in EtOAc (1 mL) was added lithium iodide (40 mg, ca. 0.3 mmol, 3.0 eq) at room temperature. The mixture was heated to 65° C. and stirred for 1 h. The reaction mixture was diluted by EtOAc (2 mL) then quenched with 1N HCl (0.5 mL). The precipitate was collected by filtration then washed with Et2O to afford the title compound as a yellow solid (20 mg, 0.061 mmol, 61%).

후처리

  1. customthen quenched with 1N HCl (0.5 mL)
  2. filtrationThe precipitate was collected by filtration
  3. washthen washed with Et2O

출처 및 근거

ORD 기록
ord-d65a66f24a76462198d42ae14b4f433d
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409905B2

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