(S)-1-Bromo-4,5-difluoro-2-(pent-4-en-2-yloxy)benzene → (S)-(4,5-Difluoro-2-(pent-4-en-2-yloxy)phenyl)boronic acid

반응식

Br[C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[O:10][C@H:11]([CH2:13][CH:14]=[CH2:15])[CH3:12].FC1C=CC([B:23]([OH:25])[OH:24])=C(O[C@H](CC=C)C)C=1>>[F:9][C:5]1[C:6]([F:8])=[CH:7][C:2]([B:23]([OH:25])[OH:24])=[C:3]([O:10][C@H:11]([CH2:13][CH:14]=[CH2:15])[CH3:12])[CH:4]=1

참가 물질

반응물 2

HCID 118308806(S)-1-Bromo-4,5-difluoro-2-(pent-4-en-2-yloxy)benzene

HCID 123945833(S)-(4-Fluoro-2-(pent-4-en-2-yloxy)phenyl)boronic acid

생성물 1

HCID 123993303(S)-(4,5-Difluoro-2-(pent-4-en-2-yloxy)phenyl)boronic acid수율 100%

실험 절차

Prepared from (S)-1-bromo-4,5-difluoro-2-(pent-4-en-2-yloxy)benzene in 100% yield following the same procedure as (S)-(4-fluoro-2-(pent-4-en-2-yloxy)phenyl)boronic acid. NMR is complex and suggests an oligomeric mixture. The material, however, was used as is and was fully compentent for undergoing a Suzuki coupling.

출처 및 근거

ORD 기록: ord-44e033bce72042d0ab4e0625910f5b41
출처 데이터셋: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09409922B2

반응 노트

불러오는 중…