참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1-Bromo-4-chlorobutane | HCID 81364 | — |
| 반응물 | 5-Fluorobenzimidazole | HCID 235698 | — |
| 촉매 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 생성물 | 1-(4-chlorobutyl)-6-fluoro-1H-benzimidazole | HCID 118386865 | 62.6% |
반응 단계
6-fluoro-1H-benzimidazole (13.2 g, 0.10 mol) was dissolved into 200 ml of 20% wt. sodium hydroxide, 4-chlorobromobutane (34.3 g, 0.20 mol) and tetrabutyl ammonium bromide (1.0 g) were added, and mixed for 5 min. The mixture was heated to 60° C., stirred to react for 2 hours. Post treatment was performed based on common method one for synthesis. Oily products were separated and purified by chromatography with neutral Al2O3 to produce 14.2 g of 1-(4-chlorobutyl)-6-fluoro-1H-benzimidazole, with a yield of 62.6%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09415047B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_08 |
|---|
| ORD ID | ord-f41fe3c1cac94ed2992c861bf9dd7823 |
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| 출처 메모 | uspto-grants-2016_08 |
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