Hydroxylamine → 5-Bromosalicylhydroxamic acid

HRID 1482862노트

반응식

HRID 1482862 반응식
[Br:1][C:2]1[CH:11]=[C:6]([C:7](OC)=[O:8])[C:5]([OH:12])=[CH:4][CH:3]=1.[NH2:13][OH:14]>O1CCOCC1.O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:12])=[C:6]([CH:11]=1)[C:7]([NH:13][OH:14])=[O:8]

참가 물질

5

반응물 2

HCID 787HydroxylamineHCID 77683Methyl 5-bromosalicylate

생성물 1

HCID 220465-Bromosalicylhydroxamic acid

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

Methyl 5-bromosalicylate (5 g, 21.6 mmol) was dissolved in 90 mL 1,4-dioxane and 10 mL water. 10 mL 50% aqueous hydroxylamine solution was added and the mixture was stirred at ambient temperature for 24 hours. After concentrating the mixture under vacuum, water was added. The formed precipitate was filtered, washed with water and dried yielding 5-bromo-N,2-dihydroxybenzamide (4.12 g, 17.76 mmol) as off-white solid.

후처리

  1. concentrationAfter concentrating the mixture under vacuum, water
  2. additionwas added
  3. filtrationThe formed precipitate was filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-b8376e5484c44bdcb4cda9ecc9ea4db0
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09416115B2

반응 노트

불러오는 중…