Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(4-Methoxy-3-methylphenyl)ethan-1-amine → N1-Ethyl-N1-(3-{2-[2-(4-methoxy-3-methyl-phenyl)-ethylamino]-pyrimidin-4-yl}-benzyl)-propane-1,3-diamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(4-Methoxy-3-methylphenyl)ethan-1-amine | HCID 6484660 | — |
| 반응물 | (3-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amino}-propyl)-carbamic acid tert-butyl ester | HCID 86603278 | — |
| 생성물 | N1-Ethyl-N1-(3-{2-[2-(4-methoxy-3-methyl-phenyl)-ethylamino]-pyrimidin-4-yl}-benzyl)-propane-1,3-diamine | HCID 67044735 | — |
반응 단계
Intermediate 3 was coupled with 2-(4-Methoxy-3-methyl-phenyl)-ethylamine following procedure F. The resulting product was deprotected by procedure G. LC-MS showed the product had the expected M+H+ of 434. 1H NMR (Varian 300 MHz, CD3OD, shifts relative to the solvent peak at 3.3 ppm) δ 8.4 (m, 2H) 8.0 (s, 1H) 7.6-7.8 (m, 2H) 7.47 (d, 1H) 6.82 (d, 1H) 6.67 (m, 2H) 4.5 (s, 2H) 3.81 (s, 3H) 3.4 (m, 4H) 3.28 (m, 4H) 3.03 (t, 2H) 2.68 (t, 2H) 2.16 (m, 2H) 1.4 (t, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732444B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-fd5d33d936f34af9836cee9ac761e6a1 |
| 출처 메모 | uspto-grants-2010_06 |