Aminopyrazine → 4-(2-{4-[3-(Pyrazin-2-ylaminomethyl)-phenyl]-pyrimidin-2-ylamino}-ethyl)-phenol

HRID 14837

반응식

HRID 14837 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][NH:10][C:11]2[N:16]=[C:15]([C:17]3[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=3)[CH:20]=O)[CH:14]=[CH:13][N:12]=2)=[CH:4][CH:3]=1.[NH2:25][C:26]1[CH:31]=[N:30][CH:29]=[CH:28][N:27]=1>>[N:27]1[CH:28]=[CH:29][N:30]=[CH:31][C:26]=1[NH:25][CH2:20][C:19]1[CH:18]=[C:17]([C:15]2[CH:14]=[CH:13][N:12]=[C:11]([NH:10][CH2:9][CH2:8][C:5]3[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=3)[N:16]=2)[CH:24]=[CH:23][CH:22]=1

참가 물질

3

반응물 2

HCID 78747AminopyrazineHCID 866032623-{2-[2-(4-Hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-benzaldehyde

생성물 1

HCID 586033834-(2-{4-[3-(Pyrazin-2-ylaminomethyl)-phenyl]-pyrimidin-2-ylamino}-ethyl)-phenol

실험 절차

Intermediate 28 was coupled with 2-aminopyrazine following procedure B. LC-MS showed the product had the expected M+H+ of 399. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) δ 8.3 (m, 2H), 8.1 (m, 1H), 8.0 (m, 3H), 7.7 (m, 2H), 7.5 (m, 3H), 7.1 (m, 2H), 6.7 (m, 2H), 4.6 (m, 2H), 3.6 (m, 2H), 2.8 (m, 2H).

출처 및 근거

ORD 기록
ord-3cb8c232762e4af394b1b080b292d32e
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732444B2

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