Ammonia tetrahydrofuran → 4-(1,3-Dioxoisoindolin-2-yl)cyclohexane-1-sulfonamide

HRID 1483836노트

반응식

HRID 1483836 반응식
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH:12]1[CH2:17][CH2:16][CH:15]([S:18](Cl)(=[O:20])=[O:19])[CH2:14][CH2:13]1.[NH3:22].C1COCC1>>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH:12]1[CH2:17][CH2:16][CH:15]([S:18]([NH2:22])(=[O:20])=[O:19])[CH2:14][CH2:13]1

참가 물질

3

반응물 2

HCID 21982362Ammonia tetrahydrofuranHCID 893896834-(1,3-Dioxoisoindolin-2-yl)cyclohexane-1-sulfonyl chloride

생성물 1

HCID 712276614-(1,3-Dioxoisoindolin-2-yl)cyclohexane-1-sulfonamide수율 64%

실험 절차

A mixture of 4-(1,3-dioxoisoindolin-2-yl)cyclohexane-1-sulfonyl chloride (5 g, 15.2 mmol) in NH3/THF (150 mL) was stirred at room temperature overnight. The mixture was concentrated in vacuo. The residue was dissolved into about 100 mL of hot water and the solid was filtered under hot condition. The filtrate was concentrated in vacuo to give 4-(1,3-dioxoisoindolin-2-yl)cyclohexane-1-sulfonamide (3 g, 64%) as an off-white solid.

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. dissolutionThe residue was dissolved into about 100 mL of hot water
  3. filtrationthe solid was filtered under hot condition
  4. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-a6f1d9add9f54c7b9d6fa704e2e9d1d0
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09416132B2

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