Thionyl Chloride → HCID 90315066, 화합물

반응식

[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:17])([F:16])[C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:20])=O>>[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:17])([F:16])[C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:7][C:3]=1[C:4]([Cl:20])=[O:5]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 469413502-Fluoro-4-(perfluoroethyl)benzoic acid

생성물 1

HCID 90315066HCID 90315066, 화합물수율 93.4%

반응 조건

온도: 60 °C

실험 절차

To 2-fluoro-4-(1,1,2,2,2-pentafluoroethyl)benzoic acid (1 g, 3.87 mmol) was added thionyl chloride (3.67 mL, 50.36 mmol) and the reaction was stirred at 60° C. for 22 hours. Excess thionyl chloride was removed in vacuo to yield 2-fluoro-4-(1,1,2,2,2-pentafluoroethyl)benzoyl chloride (1 g, 93%) as a viscous yellow liquid.

후처리

customExcess thionyl chloride was removed in vacuo

출처 및 근거

ORD 기록: ord-474a27e6b3d744aea3c360023f7d21a8
출처 데이터셋: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09421196B2

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