3-Amino-4,4,4-trifluorobut-2-enenitrile → HCID 178428402, 화합물

HRID 1484558노트

반응식

HRID 1484558 반응식
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[N:7][NH:8]2)=[CH:4][C:3]=1/[CH:12]=[C:13](/[C:16](=O)[CH3:17])\[C:14]#[N:15].[NH2:19][C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][C:22]#[N:23]>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:11])=[N:7][NH:8]2)=[CH:4][C:3]=1[CH:12]1[C:21]([C:22]#[N:23])=[C:20]([C:24]([F:27])([F:26])[F:25])[NH:19][C:16]([CH3:17])=[C:13]1[C:14]#[N:15]

참가 물질

3

반응물 2

HCID 534010963-Amino-4,4,4-trifluorobut-2-enenitrileHCID 178467934HCID 178467934, 화합물

생성물 1

HCID 178428402HCID 178428402, 화합물

실험 절차

Following the procedure described for Example 4, 250 mg (0.411 mmol) (2E)-2-[(6-fluoro-3-methyl-1H-indazol-5-yl)methylidene]-3-oxobutanenitrile (Example 4A) were treated with 3-amino-4,4,4-trifluorobut-2-enenitrile. The crude product was purified by preparative RP-HPLC (aceto-nitrile/water gradient, final mixture 90:10 v/v) to yield 159 mg (42% of th.) of the racemic title compound.

후처리

  1. customThe crude product was purified by preparative RP-HPLC (aceto-nitrile/water gradient, final mixture 90:10 v/v)

출처 및 근거

ORD 기록
ord-367fc068d524452487dfb5065f791ceb
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09422263B2

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