3-(4-Nitro-1H-pyrazol-1-yl)pyridine → Pyridine, 3-(4-aminopyrazol-1-yl)-

HRID 1484721노트

반응식

HRID 1484721 반응식
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)[CH:8]=1)([O-])=O>C1COCC1.[Pd]>[N:11]1[CH:12]=[CH:13][CH:14]=[C:9]([N:7]2[CH:8]=[C:4]([NH2:1])[CH:5]=[N:6]2)[CH:10]=1

참가 물질

4

반응물 1

HCID 126612223-(4-Nitro-1H-pyrazol-1-yl)pyridine

생성물 1

HCID 206682Pyridine, 3-(4-aminopyrazol-1-yl)-수율 122.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3-(4-nitro-pyrazol-1-yl)-pyridine (1.8 g, 0.009 mol) in dry THF (18 ml) was added 5% Pd/C (180 mg) under nitrogen atmosphere. The mixture was then stirred under hydrogen atmosphere until the reaction was complete. The reaction mixture was filtered through a pad of celite, and concentrated to dryness to give an impure dark brown solid (1.76 g): 1H NMR (400 MHz, DMSO-d6) δ 8.89 (dd, J=2.8. 0.4 Hz, 1H); 8.48 (dd, J=4.8, 1.2 Hz, 1H), 7.99-7.96 (m, 1H), 7.54 (d, J=1.2 Hz, 1H), 7.45 (d, J=0.4 Hz, 1H), 7.38-7.35 (m, 1H), 4.81 (bs 1H); ESIMS (m/z) 161 [M+1].

후처리

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-021d1614530e4605921b95de97a8d5fe
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09422278B2

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