Ethyl cyanoacetate → Ethyl 1-cyanocyclopropanecarboxylate
반응식
[C:1]([CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2].C(=O)([O-])[O-].[K+].[K+].Br[CH2:16][CH2:17]Br>CC(C)=O>[C:1]([C:3]1([C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH2:17][CH2:16]1)#[N:2]참가 물질
5
실험 절차
To a solution of ethyl cyanoacetate (11.8 g) in acetone (83.0 mL), potassium carbonate (43.1 g) and 1,2-dibromoethane (39.2 g) were added and the mixture was refluxed for 12 hours. After being cooled to room temperature, the reaction mixture was filtered through Celite (registered trademark). The filtrate was concentrated under reduced pressure and further dried under reduced pressure with heating to give ethyl 1-cyanocyclopropanecarboxylate as a red oil (14.2 g).
후처리
- temperaturethe mixture was refluxed for 12 hours
- filtrationthe reaction mixture was filtered through Celite (registered trademark)
- concentrationThe filtrate was concentrated under reduced pressure
- customfurther dried under reduced pressure
- temperaturewith heating
출처 및 근거
- ORD 기록
- ord-650f3f851e6e4dbd963a263cf0dcaa28
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09422240B2
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