Ethyl cyanoacetate → Ethyl 1-cyanocyclopropanecarboxylate

HRID 1485048

반응식

HRID 1485048 반응식
[C:1]([CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2].C(=O)([O-])[O-].[K+].[K+].Br[CH2:16][CH2:17]Br>CC(C)=O>[C:1]([C:3]1([C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH2:17][CH2:16]1)#[N:2]

참가 물질

5

반응물 3

HCID 7764Ethyl cyanoacetateHCID 78391,2-DibromoethaneHCID 11430Potassium Carbonate

생성물 1

HCID 380810Ethyl 1-cyanocyclopropanecarboxylate수율 97.8%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of ethyl cyanoacetate (11.8 g) in acetone (83.0 mL), potassium carbonate (43.1 g) and 1,2-dibromoethane (39.2 g) were added and the mixture was refluxed for 12 hours. After being cooled to room temperature, the reaction mixture was filtered through Celite (registered trademark). The filtrate was concentrated under reduced pressure and further dried under reduced pressure with heating to give ethyl 1-cyanocyclopropanecarboxylate as a red oil (14.2 g).

후처리

  1. temperaturethe mixture was refluxed for 12 hours
  2. filtrationthe reaction mixture was filtered through Celite (registered trademark)
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customfurther dried under reduced pressure
  5. temperaturewith heating

출처 및 근거

ORD 기록
ord-650f3f851e6e4dbd963a263cf0dcaa28
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09422240B2

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