Sodium sulfate decahydrate → Ctk0G8678

HRID 1485082

반응식

HRID 1485082 반응식
[C:1]1([C@H:7]2[CH2:9][C@H:8]2[C:10](OCC)=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Li+].[Al+3].[H-].[H-].[H-].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>C(OCC)C>[C:1]1([C@H:7]2[CH2:9][C@H:8]2[CH2:10][OH:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 62649Sodium sulfate decahydrateHCID 816743ethyl (1R,2S)-2-phenylcyclopropane-1-carboxylateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 11116214Ctk0G8678수율 102.9%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a solution in diethyl ether (12.0 mL) of the ethyl cis-2-phenylcyclopropanecarboxylate (1.51 g) obtained in step (1) above, a suspension of aluminum lithium hydride (393 mg) in diethyl ether (12.0 mL) was added at 0° C. After being brought to room temperature, the mixture was stirred for 2 hours. After adding sodium sulfate decahydrate at 0° C., the reaction mixture was brought to room temperature and stirred for an hour. After removing the insoluble matter by filtration, the filtrate was concentrated under reduced pressure to give (cis-2-phenylcyclopropyl)methanol as a colorless oil (1.21 g).

후처리

  1. additionwas added at 0° C
  2. customAfter being brought to room temperature
  3. customwas brought to room temperature
  4. stirringstirred for an hour
  5. customAfter removing the insoluble matter
  6. filtrationby filtration
  7. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e69db3cab39648b5968832bc46602d20
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09422240B2

연결된 노트

불러오는 중…