ethyl (1R,2S)-2-phenylcyclopropane-1-carboxylate → (3-Phenylcyclopentyl)methanol

HRID 1485095

반응식

HRID 1485095 반응식
C1([C@H]2C[C@H]2C(OCC)=O)C=CC=CC=1.C[O:16][C:17]([CH:19]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:20]1)=O>>[C:24]1([CH:21]2[CH2:22][CH2:23][CH:19]([CH2:17][OH:16])[CH2:20]2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

참가 물질

3

반응물 2

HCID 816743ethyl (1R,2S)-2-phenylcyclopropane-1-carboxylateHCID 14093250Methyl 3-phenylcyclopentane-1-carboxylate

생성물 1

HCID 13354127(3-Phenylcyclopentyl)methanol수율 86.3%

실험 절차

Instead of ethyl cis-2-phenylcyclopropanecarboxylate, 3-phenyl-cyclopentanecarboxylic acid methyl ester (1.76 g) was used and treated by the same technique as in Reference Example 23-1(2) to give (3-phenylcyclopentyl)methanol as a colorless oil (1.31 g).

후처리

  1. additiontreated by the same technique as in Reference Example 23-1(2)

출처 및 근거

ORD 기록
ord-82d2a0acb592432c81810c3a9bb3555c
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09422240B2

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