2-(3-Fluorophenyl)ethanamine → N1-Ethyl-N1-(3-{5-fluoro-2-[2-(3-fluoro-phenyl)-ethylamino]-pyrimidin-4-yl}-benzyl)-propane-1,3-diamine

참여 물질

역할	이름	HCID	투입량
반응물	2-(3-Fluorophenyl)ethanamine	HCID 533928	—
반응물	(3-{[3-(2-Chloro-5-fluoro-pyrimidin-4-yl)-benzyl]-ethyl-amino}-propyl)-carbamic acid tert-butyl ester	HCID 86603289	—
생성물	N1-Ethyl-N1-(3-{5-fluoro-2-[2-(3-fluoro-phenyl)-ethylamino]-pyrimidin-4-yl}-benzyl)-propane-1,3-diamine	HCID 58603454	—

반응 단계

Intermediate 78 was coupled with 2-(3-fluoro-phenyl)-ethylamine following procedure Q. The resulting product was deprotected following procedure R. LC-MS showed the product had the expected M+H+ of 426. 1H NMR (Varian 300 MHz, CD3OD, shifts relative to the solvent peak at 3.3 ppm) δ 8.29 (d, 1H), 8.19 (s, 2H), 7.66 (m, 2H), 6.97 (m, 4H), 4.49 (s, 2H), 3.64 (t, 2H), 3.24 (m, 4H), 2.97 (t, 2H), 2.92 (t, 2H), 2.07 (m, 2H), 1.36 (t, 3H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07732444B2
출처 데이터셋	uspto-grants-2010_06
ORD ID	ord-defd25637f274359ab7499ddbf7187ed
출처 메모	uspto-grants-2010_06