Acetyl chloride → Methyl 3-bromo-4-chlorobenzoate
반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5]([OH:7])=[O:6].[C:12](Cl)(=O)C>CO>[CH3:12][O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([Cl:11])=[C:2]([Br:1])[CH:3]=1참가 물질
4
실험 절차
To a suspension of 3-bromo-4-chloro-benzoic acid (10 g, 42.6 mmol) in MeOH (100 mL) cooled with ice bath, was added acetyl chloride (30.4 mL, 0.43 mol) dropwise. The mixture was then stirred at room temperature for 12 hrs and concentrated to yield 3-bromo-4-chloro-benzoic acid methyl ester as a yellow solid (10.6 g). NMR (CDCl3), δ, 8.28 (1H, s), 7.91 (1H, brs), 7.52 (1H, brs), 3.92 (3H, s).
후처리
- temperaturecooled with ice bath
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-7045f1b810ee45f78c6fc3bc80cd0dfd
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09422310B2
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