Thionyl Chloride → 3-Iodo-2-methoxy-benzoyl chloride

반응식

[I:1][C:2]1[C:3]([O:11][CH3:12])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6].S(Cl)([Cl:15])=O>>[I:1][C:2]1[C:3]([O:11][CH3:12])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([Cl:15])=[O:6]

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 121684323-Iodo-2-methoxybenzoic acid

생성물 1

HCID 867229723-Iodo-2-methoxy-benzoyl chloride

반응 조건

온도: 82 °C

실험 절차

To 3-iodo-2-methoxy-benzoic acid (8.29 g, 29.8 mmol) was added thionyl chloride (15 mL). The resulting solution was stirred for 2 minutes then heated to 82° C. and stirred at this temperature for 30 minutes. The solution was then concentrated under reduced pressure to give the title compound. This material was used without further purification.

후처리

stirringstirred at this temperature for 30 minutes
concentrationThe solution was then concentrated under reduced pressure

출처 및 근거

ORD 기록: ord-daa4fe77befb488383dc64d10e0c2f9c
출처 데이터셋: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09422314B2

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