2,4-Dimethoxybenzylamine → Methyl 2-(3-(2,4-dimethoxybenzylamino)cyclobutyl)acetate

HRID 1486188노트

반응식

HRID 1486188 반응식
O=[C:2]1[CH2:5][CH:4]([CH2:6][C:7]([O:9][CH3:10])=[O:8])[CH2:3]1.[CH3:11][O:12][C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=1[CH2:21][NH2:22]>[Pd].CO>[CH3:11][O:12][C:13]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=1[CH2:21][NH:22][CH:2]1[CH2:5][CH:4]([CH2:6][C:7]([O:9][CH3:10])=[O:8])[CH2:3]1

참가 물질

5

반응물 2

HCID 5972502,4-DimethoxybenzylamineHCID 57686718Methyl 2-(3-oxocyclobutyl)acetate

생성물 1

HCID 86722980Methyl 2-(3-(2,4-dimethoxybenzylamino)cyclobutyl)acetate수율 96.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To methyl 2-(3-oxocyclobutyl)acetate (426 mg) and (2,4-dimethoxyphenyl)methanamine (501 mg) in a flask was added MeOH (20 mL) and Pd/C (10%, 100 mg). The reaction mixture was stirred under hydrogen atmosphere for overnight. Catalyst was removed by filtration through the Celite pad. Removal of the solvent afforded the crude product (850 mg) which was used directly to the next step without further purification.

후처리

  1. customCatalyst was removed by filtration through the Celite pad
  2. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-316ee79ea637487faa4620d5151d7ae4
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09422314B2

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