n-Cyclohexylpiperidine-4-carboxamide → HCID 86706526, 화합물

HRID 1486697노트

반응식

HRID 1486697 반응식
ClC1C([N+]([O-])=O)=CC=CC=1C=O.C1(NC(C2CCNCC2)=O)CCCCC1.[CH:28]1([NH:34][C:35]([CH:37]2[CH2:42][CH2:41][N:40]([CH2:43][C:44]3[CH:49]=[CH:48][CH:47]=[C:46]([N+:50]([O-])=O)[C:45]=3[Cl:53])[CH2:39][CH2:38]2)=[O:36])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>>[CH:28]1([NH:34][C:35]([CH:37]2[CH2:42][CH2:41][N:40]([CH2:43][C:44]3[CH:49]=[CH:48][CH:47]=[C:46]([NH2:50])[C:45]=3[Cl:53])[CH2:39][CH2:38]2)=[O:36])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1

참가 물질

4

반응물 3

HCID 12410238n-Cyclohexylpiperidine-4-carboxamideHCID 126677132-Chloro-3-nitrobenzaldehydeHCID 867065271-(2-Chloro-3-nitro-benzyl)-piperidine-4-carboxylic acid cyclohexylamide

생성물 1

HCID 86706526HCID 86706526, 화합물

실험 절차

The title compound is prepared according to the reactions described above starting from 2-chloro-3-nitro-benzaldehyde and piperidine-4-carboxylic acid cyclohexylamide giving after reductive amination 1-(2-chloro-3-nitro-benzyl)-piperidine-4-carboxylic acid cyclohexylamide LC-MS B: tR=0.57 min; [M+H]+=380.14 and reduction with stannous chloride the title compound LC-MS A: tR=0.50 min; [M+H]+=350.20.

후처리

  1. customThe title compound is prepared

출처 및 근거

ORD 기록
ord-f2b5c8cf9e8b451690eb334efb45e56a
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428456B2

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