N-tert-butylpiperidine-4-carboxamide → 1-(5-Amino-2-methyl-benzyl)-piperidine-4-carboxylic acid tert-butylamide

HRID 1486704노트

반응식

HRID 1486704 반응식
CC1C=CC([N+]([O-])=O)=CC=1C=O.C(NC(C1CCNCC1)=O)(C)(C)C.[C:26]([NH:30][C:31]([CH:33]1[CH2:38][CH2:37][N:36]([CH2:39][C:40]2[CH:45]=[C:44]([N+:46]([O-])=O)[CH:43]=[CH:42][C:41]=2[CH3:49])[CH2:35][CH2:34]1)=[O:32])([CH3:29])([CH3:28])[CH3:27]>>[C:26]([NH:30][C:31]([CH:33]1[CH2:38][CH2:37][N:36]([CH2:39][C:40]2[CH:45]=[C:44]([NH2:46])[CH:43]=[CH:42][C:41]=2[CH3:49])[CH2:35][CH2:34]1)=[O:32])([CH3:29])([CH3:28])[CH3:27]

참가 물질

4

반응물 3

HCID 7175833N-tert-butylpiperidine-4-carboxamideHCID 126541452-Methyl-5-nitrobenzaldehydeHCID 867065361-(2-Methyl-5-nitro-benzyl)-piperidine-4-carboxylic acid tert-butylamide

생성물 1

HCID 867065351-(5-Amino-2-methyl-benzyl)-piperidine-4-carboxylic acid tert-butylamide

실험 절차

The title compound is prepared according to the reactions described for BB-5 above starting from 2-methyl-5-nitro-benzaldehyde and piperidine-4-carboxylic acid tert-butylamide yielding after reductive amination 1-(2-methyl-5-nitro-benzyl)-piperidine-4-carboxylic acid tert-butylamide; LC-MS A: tR=0.62 min; [M+H]+=334.21 followed by reduction with stannous chloride the title compound; LC-MS A: tR=0.44 min; [M+H]+=304.28.

후처리

  1. customThe title compound is prepared

출처 및 근거

ORD 기록
ord-43010248afc84310995d8406544eb9d5
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428456B2

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