3-(BOC-Amino)benzaldehyde → 1-(3-Amino-benzyl)-piperidine-4-carboxylic acid (1,1-dimethyl-propyl)-amide

HRID 1486714노트

반응식

HRID 1486714 반응식
C(O[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH:19]C(OC(C)(C)C)=O)[CH:14]=2)[CH2:8][CH2:7]1)=[O:5])C.C(OC(=O)NC1C=CC=C(C=O)C=1)(C)(C)C.[CH3:43][C:44]([NH:48]C(C1CCNCC1)=O)([CH3:47])[CH2:45][CH3:46]>>[CH3:43][C:44]([NH:48][C:4]([CH:6]1[CH2:7][CH2:8][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([NH2:19])[CH:14]=2)[CH2:10][CH2:11]1)=[O:5])([CH3:47])[CH2:45][CH3:46]

참가 물질

4

반응물 3

HCID 167407363-(BOC-Amino)benzaldehydeHCID 18071930Piperidine-4-carboxylic acid (1,1-dimethyl-propyl)-amideHCID 867065211-(3-tert-Butoxycarbonylamino-benzyl)-piperidine-4-carboxylic acid ethyl ester

생성물 1

HCID 1317368081-(3-Amino-benzyl)-piperidine-4-carboxylic acid (1,1-dimethyl-propyl)-amide

실험 절차

The title compound is prepared according to the reaction 1.001a and 1.001d described above using (3-formyl-phenyl)-carbamic acid tert-butyl ester and piperidine-4-carboxylic acid (1,1-dimethyl-propyl)-amide: LC-MS A: tR=0.48 min; [M+H]+=304.23.

출처 및 근거

ORD 기록
ord-72bdfdce92be426abad027dd37ca010b
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428456B2

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