Cyclopropylamine → 4-Fluoro-piperidine-4-carboxylic acid tert-butylamide
반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]([F:17])([C:14]([OH:16])=O)[CH2:10][CH2:9]1)=O)(C)(C)C.[CH:18]1(N)CC1.C(OC(N1CCC(C(=O)[NH:36][CH:37]2[CH2:42]CCC[CH2:38]2)CC1)=O)(C)(C)C>>[C:37]([NH:36][C:14]([C:11]1([F:17])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:16])([CH3:42])([CH3:18])[CH3:38]참가 물질
4
실험 절차
The title compound is prepared according to the reaction sequence 3.01a-2.01b described above using 1-(tert-butoxycarbonyl)-4-fluoropiperidine-4-carboxylic acid instead of 1-(tert-butoxycarbonyl)-piperidine-4-carboxylic acid and cyclopropylamine instead of cyclohexylamine as in 3.01a: LC-MS A: tR=0.41 min; [M+H]+=197.35.
출처 및 근거
- ORD 기록
- ord-bef1bbd76f9244e8a58747773c974deb
- 출처 데이터셋
- uspto-grants-2016_08
- 특허 번호
- US09428456B2
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