2,4-dimethyl-N-(2-methylpropyl)aniline → 4-bromo-N-(2,4-dimethylphenyl)-3,5-difluoro-N-isobutylbenzenesulfonamide

HRID 1487061노트

반응식

HRID 1487061 반응식
[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([S:9](Cl)(=[O:11])=[O:10])=[CH:4][C:3]=1[F:13].[CH2:14]([NH:18][C:19]1[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][C:20]=1[CH3:26])[CH:15]([CH3:17])[CH3:16]>N1C=CC=CC=1>[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([S:9]([N:18]([C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][C:20]=2[CH3:26])[CH2:14][CH:15]([CH3:17])[CH3:16])(=[O:11])=[O:10])=[CH:4][C:3]=1[F:13]

참가 물질

4

반응물 2

HCID 284223892,4-dimethyl-N-(2-methylpropyl)anilineHCID 447175164-Bromo-3,5-difluorobenzenesulphonyl chloride

생성물 1

HCID 898759904-bromo-N-(2,4-dimethylphenyl)-3,5-difluoro-N-isobutylbenzenesulfonamide

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
20 °C

실험 절차

To a solution of 4-bromo-3,5-difluorobenzene-1-sulfonyl chloride (1462 mg, 5.02 mmol) in pyridine (10 mL) at 20° C. was added N-isobutyl-2,4-dimethylaniline (889 mg, 5.01 mmol) and the reaction mixture was stirred at 20° C. for 2 hours. The reaction mixture was then evaporated in vacuo and redissolved in ethyl acetate. The organic phase was washed with saturated sodium carbonate (25 mL), dried using a hydrophobic frit and evaporated in vacuo to give the required product as a yellow oil, 2.06 g. LCMS [LCMS2] Rt 1.57 min, m/z (ES+) 432/434 (M+H).

후처리

  1. customThe reaction mixture was then evaporated in vacuo
  2. dissolutionredissolved in ethyl acetate
  3. washThe organic phase was washed with saturated sodium carbonate (25 mL)
  4. customdried
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-e36bc4801cae4e77bf7e2d48c28485fb
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428452B2

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