Triethylsilane → 2-(3-Aminophenoxy)-N-cyclopropylacetamide

HRID 1487107노트

반응식

HRID 1487107 반응식
C([SiH](CC)CC)C.[CH:8]1([NH:11][C:12](=[O:24])[CH2:13][O:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-])=O)[CH:16]=2)[CH2:10][CH2:9]1>CO.[Pd]>[NH2:21][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][CH:18]=1)[O:14][CH2:13][C:12]([NH:11][CH:8]1[CH2:9][CH2:10]1)=[O:24]

참가 물질

5

반응물 2

HCID 12052TriethylsilaneHCID 7865440N-cyclopropyl-2-(3-nitrophenoxy)acetamide

생성물 1

HCID 167764562-(3-Aminophenoxy)-N-cyclopropylacetamide수율 81.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Triethylsilane (27.0 ml, 169 mmol) was added dropwise to a suspension of N-cyclopropyl-2-(3-nitrophenoxy)acetamide (4 g, 16.93 mmol) and Pd/C (10%, 400 mg) in MeOH (50 ml). Resulting suspension was stirred at RT for 20 min. and filtered through celite. The filtrate was evaporated under vacuum and triturated in hexane to obtain the crystals which were collected by filtration to afford 2-(3-aminophenoxy)-N-cyclopropylacetamide (2.86 gm).

후처리

  1. customResulting suspension
  2. filtrationfiltered through celite
  3. customThe filtrate was evaporated under vacuum
  4. customtriturated in hexane
  5. customto obtain the crystals which
  6. filtrationwere collected by filtration

출처 및 근거

ORD 기록
ord-f1f59e9fc0f743aab7ae0aa275862ea3
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428499B2

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