Ammonia → HCID 89815111, 화합물

HRID 1487115노트

반응식

HRID 1487115 반응식
[F:1][C:2]([F:17])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1)[C:3](OCC)=[O:4].[NH3:18]>>[F:1][C:2]([F:17])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1)[C:3]([NH2:18])=[O:4]

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 53419335Benzeneacetic acid, α,α-difluoro-3-nitro-, ethyl ester

생성물 1

HCID 89815111HCID 89815111, 화합물

반응 조건

온도
75 °C

실험 절차

A solution of ethyl 2,2-difluoro-2-(3-nitrophenyl)acetate (0.701 g, 2.86 mmol) in Methanolic ammonia (7M, 20.0 ml) was taken in sealed tube. Resulting mixture was heated at 75° C. for 3 hrs. The reaction mixture was concentrated under vacuum and cold water was added to obtain the precipitate. Solid was filtered to obtain 2,2-difluoro-2-(3-nitrophenyl)acetamide (0.515 g).

후처리

  1. customResulting mixture
  2. concentrationThe reaction mixture was concentrated under vacuum and cold water
  3. additionwas added
  4. customto obtain the precipitate
  5. filtrationSolid was filtered

출처 및 근거

ORD 기록
ord-8c95057f9b114a829ccbb2c6e29538df
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428499B2

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