Triethylsilane → HCID 89815378, 화합물

HRID 1487116노트

반응식

HRID 1487116 반응식
[F:1][C:2]([F:15])([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[CH:7]=1)[C:3]([NH2:5])=[O:4].C([SiH](CC)CC)C>CO.[Pd]>[NH2:12][C:8]1[CH:7]=[C:6]([C:2]([F:1])([F:15])[C:3]([NH2:5])=[O:4])[CH:11]=[CH:10][CH:9]=1

참가 물질

5

반응물 2

HCID 12052TriethylsilaneHCID 89815111HCID 89815111, 화합물

생성물 1

HCID 89815378HCID 89815378, 화합물수율 69.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a stirred solution of 2,2-difluoro-2-(3-nitrophenyl)acetamide (0.5 g, 2.313 mmol) in methanol (20 ml) was added Pd—C (100 mg) followed by slow addition of triethylsilane (3.7 ml, 23.13 mmol) at RT. The reaction was stirred at same temperature for 30 min. The reaction mixture was filtered through celite bed and washed with methanol (50 ml). Filtrate was collected and concentrated under vacuum to get 2-(3-aminophenyl)-2,2-difluoroacetamide (0.301 g).

후처리

  1. filtrationThe reaction mixture was filtered through celite bed
  2. washwashed with methanol (50 ml)
  3. customFiltrate was collected
  4. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-e965fd3680d4426a8ddc72ce79c6bdb7
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428499B2

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