Triethylsilane → 3-((4-Methyl-1-piperazinyl)carbonyl)aniline

HRID 1487151노트

반응식

HRID 1487151 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-])=O)[CH:11]=2)=[O:9])[CH2:4][CH2:3]1.C([SiH](CC)CC)C>CO.[Pd]>[NH2:16][C:12]1[CH:11]=[C:10]([C:8]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)=[O:9])[CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 2

HCID 12052TriethylsilaneHCID 763411(4-Methylpiperazin-1-yl)(3-nitrophenyl)methanone

생성물 1

HCID 167732183-((4-Methyl-1-piperazinyl)carbonyl)aniline수율 85%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a stirred solution of (4-methylpiperazin-1-yl)(3-nitrophenyl)methanone (5.5 g, 22.06 mmol) in MeOH (50 ml) was added Pd—C (10%, 0.470 g) followed by triethylsilane (14.10 ml, 88 mmol) (slow addition) at RT. The reaction mixture was stirred at same temperature for 25 min and filtered through celite, washed with methanol (50 ml). The Filtrate was concentrated under vacuum to get the title product (4.11 g).

후처리

  1. filtrationfiltered through celite
  2. washwashed with methanol (50 ml)
  3. concentrationThe Filtrate was concentrated under vacuum

출처 및 근거

ORD 기록
ord-ec4c6f4b15364f1c9ba93fb08e74acc5
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428499B2

반응 노트

불러오는 중…